DksA Guards Elongating RNA Polymerase against Ribosome-Stalling-Induced Arrest
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چکیده
منابع مشابه
DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest.
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independently of local noise and used it to reveal that the transcription factor DksA inhibits promoter-prox...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2014
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2014.02.005