Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes
نویسندگان
چکیده
منابع مشابه
Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes.
BACKGROUND Folate metabolism is critical to embryonic development, influencing neural tube defects (NTD) and recurrent early pregnancy loss. Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss. METHODS The C677T and A1298C polymorphisms in MTHFR were genotyped in 258 Australasian families (1016 individuals)...
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BACKGROUND Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates. METHODS To investigate the role of BMP15 in human twinning, we typed 14 common variants, 4 rare novel variants initially detected by sequencing 279 mothers of DZ twins (MODZT) ...
متن کاملDizygotic twinning.
The tendency to conceive spontaneous dizygotic (DZ) twins is a complex trait with important contributions from both environmental factors and genetic disposition. Twins are relatively common and occur on average 13 times per 1000 maternities, though the twinning frequency varies over time and geographic location. This variation is mostly attributed to the differences in DZ twinning rate, since ...
متن کاملIs methylenetetrahydrofolate reductase C677T polymorphism associated with hyperuricemia?
Several epidemiological studies have examined the relationship of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with hyperuricemia. However, the results were controversial. We therefore conducted a large cross-sectional study (2,219 subjects) and an updated meta-analysis by combining previous studies (9,502 subjects) to provide more empirical evidence for the association. A...
متن کاملIs fragile X syndrome a risk factor for dizygotic twinning?
Several researchers have looked for an association between fragile X (FRAXA) syndrome and dizygotic (DZ) twinning. Fryns [1986] reported a 4-fold increase in twinning in a study of 134 obligate FRAXA carriers, while Turner et al. [1994] noted a twinning rate of one in 11 in 253 carriers of the FRAXA premutation. On the other hand, Sherman et al. [1988] found no excess of twins in fragile X pedi...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2003
ISSN: 1460-2350
DOI: 10.1093/humrep/deg441