منابع مشابه
The low incidence of diversity-generating retroelements in sequenced genomes
The insertion of a retrotransposable element is usually associated with adverse or, at best, neutral effects on the host. Diversity-generating retroelements (DGRs) are the first elements that seem to offer a direct selective advantage to their phage or prokaryote host by exact replacement of a short, defined region of a host gene with a hypermutated variant. In a previous study, we presented th...
متن کاملIdentification of Diversity-Generating Retroelements in Human Microbiomes
Diversity-generating retroelements (DGRs) are a unique family of retroelements that confer selective advantages to their hosts by accelerating the evolution of target genes through a specialized, error-prone, reverse transcription process. First identified in a Bordetella phage (BPP-1), which mediates the phage tropism specificity by generating variability in an involved gene, DGRs were predict...
متن کاملCore Concepts: How diversity-generating retroelements promote mutation and adaptation in myriad microbes.
Adaptation, a cornerstone of evolutionary change, is rarely straightforward. Acquiring a random mutation that promotes survival can take generations. Prokaryotes such as bacteria and Archaea, along with the viruses they harbor, have compact genomes, leaving them with a limited repertoire of DNA to respond to environmental change. Fifteen years ago, microbiologist Jeffrey Miller at the Universit...
متن کاملGenomic and Metagenomic Analysis of Diversity-Generating Retroelements Associated with Treponema denticola
Diversity-generating retroelements (DGRs) are genetic cassettes that can produce massive protein sequence variation in prokaryotes. Presumably DGRs confer selective advantages to their hosts (bacteria or viruses) by generating variants of target genes-typically resulting in target proteins with altered ligand-binding specificity-through a specialized error-prone reverse transcription process. T...
متن کاملDiversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey
Diversity-generating retroelements (DGRs) are novel genetic elements that use reverse transcription to generate vast numbers of sequence variants in specific target genes. Here, we present a detailed comparative bioinformatic analysis that depicts the landscape of DGR sequences in nature as represented by data in GenBank. Over 350 unique DGRs are identified, which together form a curated refere...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2007
ISSN: 1369-5274
DOI: 10.1016/j.mib.2007.06.004