Diversification and collapse of a telomere elongation mechanism
نویسندگان
چکیده
منابع مشابه
Separating the effects of telomere size from the mechanism of telomere elongation
A study published in this issue of EMBO Journal dissects the properties of elongated telomeres generated by telomerase as opposed to alternative (ALT) recombination mechanisms. In a result that breaks with the current paradigm, Pickett et al find that many characteristics previously ascribed to the ALT pathway are the property of the elongated telomere itself. Telomeres are the nucleoprotein st...
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Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which trigger the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as a therapeutic target. Using an unbiased shRNA screen targeting known kinases, we identified bromodomain-containing protein 4 (BRD4) as a telomere lengt...
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Telomere elongation by telomerase balances the progressive shortening of chromosome ends due to the succession of replication cycles [1] [2]. Telomerase activity is regulated in vivo at its site of action by the telomere itself. In yeast and human cells, the mean telomere length is maintained at a constant value through a cis-inhibition of telomerase by factors specifically bound to the telomer...
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15 صفحه اولHuman POT1 Facilitates Telomere Elongation by Telomerase
Mammalian telomeric DNA is mostly composed of double-stranded 5'-TTAGGG-3' repeats and ends with a single-stranded 3' overhang. Telomeric proteins stabilize the telomere by protecting the overhang from degradation or by remodeling the telomere into a T loop structure. Telomerase is a ribonucleoprotein that synthesizes new telomeric DNA. In budding yeast, other proteins, such as Cdc13p, that may...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2019
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.245001.118