Diuretic Response to Chlorthalidone

Chlorthalidone: has it always been the best thiazide-type diuretic?

Modern diuretic therapy evolved from 2 seemingly unrelated events in the 1930s: the development of sulfanilamide, the first truly effective antibacterial agent, and the description of the enzyme carbonic anhydrase. Sulfanilamide was observed to increase sodium (Na )/potassium and water excretion by inhibition of carbonic anhydrase activity. Recognition of this action proved the impetus for synt...

Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison

We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare ...

Chlorthalidone versus hydrochlorothiazide as the preferred diuretic: is there a verdict yet?

In this issue of Hypertension, the retrospective observational cohort analysis of the Multiple Risk Factor Intervention Trial by Dorsch et al1 adds to the growing body of evidence supporting the superiority of chlorthalidone over hydrochlorothiazide (HCTZ) as the preferred diuretic in the treatment of hypertension. In the absence of a randomized, controlled clinical end point trial directly com...

Author ' s response to reviews Title : Improved persistence and adherence to diuretic fixed - dose combination therapy compared to diuretic monotherapy

Diurnal variation in the diuretic response to ingested water.

In normal individuals the renal excretion of water, sodium, potassium, and uric acid is less at night than during the day. This diurnal variation persists when no food or fluids are taken as well as when identical quantities of food, fluid, and electrolyte are ingested at regular intervals throughout the 24-hour period and is not easily altered by changes in the cycle of sleep and activity (1-1...