Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low‐dose loop diuretic therapy

Aims To study loop diuretic response and effect of omission in ambulatory heart failure (HF) patients on chronic low-dose diuretics. Methods results Urine collections were performed two consecutive days 40 HF with 40–80 mg furosemide (day 1 diuretic; day 2 without diuretic). Three phases collected each day: (i) first 6 h; (ii) rest the day; (iii) night. On intake, total natriuresis was 125.9 (86.9–155.0) mmol/24 h urine output 1650 (1380–2025) mL/24 h. There a clear 9.4 (6.7–15.9) mmol/h 117 (83–167) mL/h during h, followed by significant drop [2.6 (1.8–4.8) 55 (33–71) mL/h] night [2.2 (1.6–3.5) 44 (34–73) mL/h]. 2, after omission, remained similarly low entire day, resulting 50% reduction [55.1 (33.5–77.7) P < 0.001] 31% [1035 (875–1425) compared intake. Conclusion Patients treatment still have phase, while leads to output, arguing against routine cessation