منابع مشابه
Diuretic therapy and diuretic resistance in cardiac failure.
s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...
متن کاملSystems biology of diuretic resistance.
Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall...
متن کاملMechanistic insights into diuretic-induced insulin resistance.
The incidence of diabetes mellitus and hypertension continues to rise worldwide. The proportion of patients with hypertension at risk for developing diabetes mellitus is also growing secondary to aging and increased obesity rates.1 Several guidelines recommend thiazide diuretics as either first-line or add-on antihypertensive therapy to achieve blood pressure goals.2 Concern over negative metab...
متن کاملHypochloremia and Diuretic Resistance in Heart Failure
The fundamental role of sodium in maintenance of fluid homeostasis and progression of heart failure (HF) has been a central paradigm in medicine for more than a century. As a result, a core treatment principal in HF management has been the avoidance of dietary sodium. However, accumulating evidence ranging from the basic sciences to epidemiological studies has challenged this paradigm, suggesti...
متن کاملMechanisms and management of diuretic resistance in congestive heart failure.
Diuretic drugs are used almost universally in patients with congestive heart failure, most frequently the potent loop diuretics. Despite their unproven effect on survival, their indisputable efficacy in relieving congestive symptoms makes them first line therapy for most patients. In the treatment of more advanced stages of heart failure diuretics may fail to control salt and water retention de...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2017
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2016.08.027