منابع مشابه
Synthesis of Zinc Dimethyldithiocarbamate by Reductive Disulfide Bond Cleavage of Tetramethylthiuram Disulfide in Presence of Zn2+
The zinc(II) complex [Zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = N,N-dimethyldithiocarbamate; thiram = N,N-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. Surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with Zn2+ in methanolic media to give the [Z...
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Reduction of the single disulfide bond between heavy chains in the hinge region of rabbit IgG antibody causes destabilization of the CH2 region of the molecule. Our studies indicate that reduced antibody molecules undergo a large change in quaternary structure in the CH2 region upon aggregation with a small bivalent hapten. The conformational change was observed both in hydrodynamic studies and...
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We present a computational study of a recently developed molecular fractionation with conjugated caps (MFCC) method for application to peptide/protein that has disulfide bonds. Specifically, we employ the MFCC approach to generate peptide fragments in which a disulfide bond is cut and a pair of conjugated caps are inserted. The method is tested on two peptides interacting with a water molecule....
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Proteins with multiple cysteine residues often require disulfide isomerization reactions before they attain their correct conformation. In prokaryotes this reaction is catalyzed mainly by DsbC, a protein that shares many similarities in structure and mechanism to the eukaryotic protein disulfide isomerase. This review discusses the current knowledge about disulfide isomerization in prokaryotes.
متن کاملsynthesis of zinc dimethyldithiocarbamate by reductive disulfide bond cleavage of tetramethylthiuram disulfide in presence of zn2+
the zinc(ii) complex [zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = n,n-dimethyldithiocarbamate; thiram = n,n-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with zn2+ in methanolic media to give the [z...
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ژورنال
عنوان ژورنال: mAbs
سال: 2012
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.4.1.18347