Disturbed Microcirculation as Cause

Disturbed acid-base transport: an emerging cause of hypertension

Genome-wide association studies and physiological investigations have linked alterations in acid-base transporters to hypertension. Accordingly, Na(+)-coupled HCO(-) 3-transporters, Na(+)/H(+)-exchangers, and anion-exchangers have emerged as putative mechanistic components in blood pressure disturbances. Even though hypertension has been studied extensively over the last several decades, the ca...

The microcirculation as a functional system

This review examines experimental evidence that the microvascular dysfunction that occurs early in sepsis is the critical first stage in tissue hypoxia and organ failure. A functional microvasculature maintains tissue oxygenation despite limitations on oxygen delivery from blood to tissue imposed by diffusion; the density of perfused (functional) capillaries is high enough to ensure appropriate...

Disturbed families, or families disturbed?

Gutterman et al Regulation of the Human Microcirculation 159 Microcirculation as a Window Into Conduit

Tasked with providing nutrients and removing metabolic byproducts from virtually all living cells in the body, the microcirculation plays a critical but indirect role in tissue function. Herein lies a major challenge. The microcirculation must maximize the distribution of nutrients and oxygen by touching nearly every living cell, while minimizing the space it occupies to allow room for the netw...

Gutterman et al Regulation of the Human Microcirculation 159 Microcirculation as a Window Into

Tasked with providing nutrients and removing metabolic byproducts from virtually all living cells in the body, the microcirculation plays a critical but indirect role in tissue function. Herein lies a major challenge. The microcirculation must maximize the distribution of nutrients and oxygen by touching nearly every living cell, while minimizing the space it occupies to allow room for the netw...