Distribution of voltage sensors in mammalian outer hair cells
نویسندگان
چکیده
منابع مشابه
Somatic stiffness of cochlear outer hair cells is voltage-dependent.
The mammalian cochlea depends on an amplification process for its sensitivity and frequency-resolving capability. Outer hair cells are responsible for providing this amplification. It is usually assumed that the membrane-potential-driven somatic shape changes of these cells are the basis of the amplifying process. It is of interest to see whether mechanical reactance changes of the cells might ...
متن کاملComparison of isolated outer hair cells from five mammalian species.
Live outer hair cells were isolated from guinea pig, chinchilla, rat, mouse, and gerbil. The organ of Corti from selected turns of the cochlea was briefly incubated with collagenase and outer hair cells were separated from the tissue by micromanipulation under microscopic observation. Morphological criteria for cell viability were: cylindrical cell shape without swelling or distortion of the me...
متن کاملAsymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti.
The electrically induced movements of outer hair cells (OHC) were studied using the whole-cell voltage-clamp technique and video analysis. Cell shortening occurs during depolarization and elongation occurs during hyperpolarization from holding potentials near -70 mV. However, a marked asymmetry in response magnitude exists such that depolarization produces larger cell length changes than do com...
متن کاملTwo types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea
Van Den Abbeele, Thierry, Jacques Teulon, and Patrice Tran Ba Huy. Two types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea. Am. J. Physiol. 277 (Cell Physiol. 46): C913–C925, 1999.— Cell-attached and cell-free configurations of the patch-clamp technique were used to investigate the conductive properties and regulation of the major K1 channels in the bas...
متن کاملTwo types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea.
Cell-attached and cell-free configurations of the patch-clamp technique were used to investigate the conductive properties and regulation of the major K+channels in the basolateral membrane of outer hair cells freshly isolated from the guinea pig cochlea. There were two major voltage-dependent K+ channels. A Ca2+-activated K+ channel with a high conductance (220 pS, P K/ P Na= 8) was found in a...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1993
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(93)81232-3