Distribution of A23187 in cloned rabbit aortic smooth muscle celles
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چکیده
منابع مشابه
Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy.
We investigated the impairment of ATP-sensitive K(+) (K(ATP)) channels in aortic smooth muscle cells (ASMCs) from isoproterenol-induced hypertrophied rabbits. The amplitude of K(ATP) channels induced by the K(ATP) channel opener pinacidil (10 μM) was greater in ASMCs from control than from hypertrophied animals. In phenylephrine-preconstricted aortic rings, pinacidil induced relaxation in a dos...
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Studies on hormone induced contraction of vascular smooth muscle strips in vitro have yielded a large body of pharmacological and biochemical data (1). Unfortunately, vascular strips possess inherent limitations for answering certain questions concerning sites of hormone binding on their constituent smooth muscle cells. Diffusion barriers in the tissue may hinder the use of macromolecular recep...
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A sensitive radioisotope microassay has been developed for the estimation of cholesteryl ester hydrolase (EC 3.1.1.13) in preparations of isolated rabbit aortic smooth muscle cells. Kinetic studies served to establish optimal assay conditions, which involve incubation in a total volume of 0.2 ml containing 5 pM cholesteryl oleate tritiated in the cholesterol moiety, 0.4 mM egg yolk lecithin, 0....
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The effects of elevated potassium ion (K) concentration on radioactive calcium (Ca) movements and distribution were investigated in media-intimal strips prepared from rabbit aortic smooth muscle. Ca uptake was measured in either normal (1.5 rriM Ca ) or low-Ca (0.1 mM Ca ) solutions. In low-Ca solutions, elevating the K concentration either by substituting equimolar (165.4 IHM) K for sodium (Na...
متن کاملLysophosphatidylcholine potentiates the mitogenic effect of various vasoactive compounds on rabbit aortic smooth muscle cells.
We examined the mechanism of action of lysophosphatidylcholine (lyso-PC), which is suggested to be involved in the pathogenesis of atherosclerosis and inflamatory disorders, and its interaction with well-known vasoactive compounds such as hydrogen peroxide (H2O2), thromboxane A2 (TX-A2), serotonin (5-HT), angiotensin II (Ang-II), endothelin-1 (ET-1), or urotensin II (U-II) on VSMC proliferation...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1984
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)62576-x