Distinct Molecular Trajectories Converge to Induce Naive Pluripotency
نویسندگان
چکیده
منابع مشابه
Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency
Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into the mechanism by which Wnt/β-catenin regulates ESC fate, we screened and characterized its downstream targets. Here, we show that the self-renewal-promoting effect of Wnt/β-catenin signaling is mainly mediated by two of its downstream tar...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2019
ISSN: 1934-5909
DOI: 10.1016/j.stem.2019.07.009