Distinct genetic regions modify specific muscle groups in muscular dystrophy
نویسندگان
چکیده
منابع مشابه
Distinct genetic regions modify specific muscle groups in muscular dystrophy.
Phenotypic expression in the muscular dystrophies is variable, even with the identical mutation, providing strong evidence that genetic modifiers influence outcome. To identify genetic modifier loci, we used quantitative trait locus mapping in two differentially affected mouse strains with muscular dystrophy. Using the Sgcg model of limb girdle muscular dystrophy that lacks the dystrophin-assoc...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2011
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00172.2010