Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
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چکیده
منابع مشابه
Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
The cochlea and vestibular structures of the inner ear labyrinth develop from the otic capsule via step-wise regional and cell fate specification. Each inner ear structure contains a sensory epithelium, composed of hair cells, the mechanosensory transducers, and supporting cells. We examined the spatio-temporal expression of genes in the Notch signaling pathway, Notch receptors (Notch1-4) and t...
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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.
The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic. Notch-mediated lateral inhibition is the proposed mechanism for creating this sensory mosaic. Previous work has shown that mice lacking the Notch ligand JAG2 differentiate supernumerary hair cells in the cochlea, consistent with the la...
متن کاملThe Role of Notch Ligands in Development of the Inner Ear
The sensory epithelium of the inner ear consists of a mosaic pattern of hair cells separated from one another by supporting cells. The Notch signalling pathway is thought to establish this pattern through a process of lateral inhibition, and has recently been shown to have an early role in inducing sensory patch formation. Several Notch ligands are expressed in the developing sensory patch, but...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1998
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(98)00165-8