Dissolution Testing of Sublingual Tablets: A Novel In Vitro Method
نویسندگان
چکیده
منابع مشابه
Dissolution testing of orally disintegrating tablets.
For industrially manufactured pharmaceutical dosage forms, product quality tests and performance tests are required to ascertain the quality of the final product. Current compendial requirements specify a disintegration and/or a dissolution test to check the quality of oral solid dosage forms. These requirements led to a number of compendial monographs for individual products and, at times, the...
متن کاملDevelopment and Validation of a Discriminatory Dissolution Testing Method for Orally Disintegrating Tablets (ODTs) of Domperidone
The orally disintegrating tablet (ODT) is a novel dosage form that disintegrates in the oral cavity using saliva as the disintegrating medium and is swallowed as a fine dispersion. Due to rapid disintegration, the dissolution rate is controlled by the intrinsic solubility of the API; therefore, it is difficult to evaluate the effect of formulation and processing parameters on in vitro drug rele...
متن کاملComparative in vitro dissolution study of Aceclofenac Marketed Tablets in Two Different Dissolution Media by Validated Analytical Method
In this study five marketed brands of aceclofenac 100 mg tablets have been evaluated using dissolution test in two different media with the aim to assess bioequivalence and to select a proper dissolution medium. Other general quality parameters of these tablets like weight variation, hardness, friability, disintegration time were also determined according to established protocols. All the brand...
متن کاملIn Vitro Dissolution Profile of Dapagliflozin: Development, Method Validation, and Analysis of Commercial Tablets
Dapagliflozin was the first of its class (inhibitors of sodium-glucose cotransporter) to be approved in Europe, USA, and Brazil. As the drug was recently approved, there is the need for research on analytical methods, including dissolution studies for the quality evaluation and assurance of tablets. The dissolution methodology was developed with apparatus II (paddle) in 900 mL of medium (simula...
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Enrofloxacin is a fluoroquinolone for veterinary use; it has low aqueous solubility and relatively high permeability. Dissolution may be the limiting step in absorption for solid dosage forms having these characteristics. Considering this, in vitro dissolution tests are indicated to evaluate batch-to-batch quality and to support pharmaceutical equivalence studies. In this study, an alternative ...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2011
ISSN: 1530-9932
DOI: 10.1208/s12249-011-9615-0