Dissociation between mitochondria calcium ion release and pyridine nucleotide oxidation.
نویسندگان
چکیده
منابع مشابه
Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides.
Mitochondria from normal rat liver and heart, and also Ehrlich tumor cells, respiring on succinate as energy source in the presence of rotenone (to prevent net electron flow to oxygen from the endogenous pyridine nucleotides), rapidly take up Ca(2+) and retain it so long as the pyridine nucleotides are kept in the reduced state. When acetoacetate is added to bring the pyridine nucleotides into ...
متن کاملN-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.
The mechanism of N-acetyl-p-benzoquinone imine (NAPQI)-induced release of Ca2+ from rat liver mitochondria was investigated. The addition of NAPQI or 3,5-Me2-NAPQI (a dimethylated analogue of NAPQI with only oxidizing properties) to mitochondria resulted in the rapid and extensive oxidation of NADH and NADPH. High-performance liquid chromatographic analysis of mitochondrial pyridine nucleotides...
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The processes of excitation–contraction (EC) coupling consume large amounts of energy that need to be replenished by oxidative phosphorylation in the mitochondria. Since Ca2+ activates key enzymes of the Krebs cycle in the mitochondrial matrix, it is important to understand the mechanisms and kinetics of mitochondrial Ca2+ uptake to delineate how in cardiac myocytes, energy supply is efficientl...
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A number of advances have been made recently in our knowledge of the mechanisms of mitochondrial Ca2+ transport, and these offer new perspectives to the problem of why mitochondria transport Cal+. Progress with cardiac mitochondria has been favoured by the resolution of the overall flux of Caz+ across the inner membrane into two distinct components, which represent catalysis by two separate car...
متن کاملOn the inter-relationship between glucagon action, the oxidation-reduction state of pyridine nucleotides, and calcium retention by rat liver mitochondria.
Experiments were performed to investigate the proposition (Lehninger, A. L., Vercesi, A., and Bababunmi, E. A. (1978) Proc. Natl. Acad Sci. U. S. A. 75,1690-1694) that the oxidation-reduction state of mitochondrial pyridine nucleotides is a determinant in the ability of mitochondria to retain ca’+. Use was made of the fact that glucagon administration to rats in vivo induces a stable enhancemen...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70471-2