Dissecting mitosis
نویسندگان
چکیده
منابع مشابه
Dissecting mitosis with laser microsurgery and RNAi in Drosophila cells.
Progress from our present understanding of the mechanisms behind mitosis has been compromised by the fact that model systems that were ideal for molecular and genetic studies (such as yeasts, C. elegans, or Drosophila) were not suitable for intracellular micromanipulation. Unfortunately, those systems that were appropriate for micromanipulation (such as newt lung cells, PtK1 cells, or insect sp...
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متن کاملModeling mitosis.
The mitotic spindle is a fascinating protein machine that uses bipolar arrays of dynamic microtubules and many mitotic motors to coordinate the accurate segregation of sister chromatids. Here we discuss recent mathematical models and computer simulations that, in concert with experimental studies, help explain the molecular mechanisms by which the spindle machinery performs its crucial function...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2892