منابع مشابه
Amelogenin Nanospheres Supra-Molecular Assembly and the Preferential Orientation of Apatite Crystals
Dental enamel is a bio-ceramic formed through a cascade of intra and extra-cellular events among which protein self-assembly is a critical step. Amelogenin selfassembly into nanospheres has been proposed as a key factor in controlling the oriented and elongated growth of enamel crystals. This manuscript is a short review of our recent in vitro study on the process of amelogenin selfassembly int...
متن کاملAmelogenin Supramolecular Assembly in Nanospheres Defined by a Complex Helix-Coil-PPII Helix 3D-Structure
Tooth enamel, the hardest material in the human body, is formed within a self-assembled matrix consisting mostly of amelogenin proteins. Here we have determined the complete mouse amelogenin structure under physiological conditions and defined interactions between individual domains. NMR spectroscopy revealed four major amelogenin structural motifs, including an N-terminal assembly of four α-he...
متن کاملAmelogenin is a cell adhesion protein.
Amelogenin, the major protein component of tooth enamel, is shown to be a cell adhesion protein. Since it had been shown that an amelogenin-containing preparation, Emdogain, possessed cell-adhesive activity, we tested the hypothesis that amelogenin was responsible for cell-adhesive activity. Recombinant amelogenin was found to promote adhesion at less than 15 micro g/60-mm plate and requires di...
متن کاملAmelogenin: a Protein to Smile About
How did we humans (and other vertebrates) get our sparkling smiles? The hard white coating on our teeth, the enamel, is made up of hydroxyapatite—the same mineral that forms our bones. In our teeth, hydroxyapatite is organized into parallel arrays of columnar apatite crystals called prisms. The growth and organization of enamel prisms is controlled by special proteins secreted by cells known as...
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Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensively recently and this review will point you towards some of these excellent pa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.250928