"Disposition" and the Specific Allergen in Asthma, etc
نویسندگان
چکیده
منابع مشابه
Allergen-Specific Immunotherapy in Asthma
Current asthma therapies can effectively control symptoms and the on-going inflammatory process; however, they do not affect the underlying, dysregulated immune response. Thus, they are limited to blunting the progression of the disease, which relapses on ceasing the treatment. Allergen-specific immunotherapy (AIT) is the only etiology-based treatment capable of disease modification. Recent evi...
متن کاملAllergen Specific Immunotherapy in Asthma
The use of allergen-Specific Immunotherapy (SIT) to treat asthma remains one of the most debated aspects in the field since several decades. The available guidelines provide no clear or unequivocal indication, stating only that SIT is specific for the allergen causing the allergic disease (rhinitis and/or asthma) and not for the disease itself [1]. Nonetheless, in the majority of the clinical t...
متن کاملAllergen-specific immunotherapy in pediatric allergic asthma
Allergen-specific immunotherapy (AIT) is the only curative way that can change the immunologic response to allergens and thus can modify the natural progression of allergic diseases. There are some important criteria which contributes significantly on efficacy of AIT, such as the allergen extract used for treatment, the dose and protocol, patient selection in addition to the severity and contro...
متن کامل[Human lymphocyte blasttransformation in bronchial asthma and drug hypersensitivity induced by asthma allergen or specific drug].
概要 即 時型 ア レルギ ー とされ る気管支喘 息,薬 物過敏症 を有す る症例 の末梢 血 リンパ球 をそれぞれ のア レル ゲン水 溶液(気 管支喘 息 では皮膚 試験陽性 を示 したハ ウスダス ト,真 菌類,ブ タ クサ等,薬 物 は起 因薬物 と考え られ る もの)の適量 で,培 養液TC199,自 己血漿 と共 に5日 間培養 し,お のお の 約60%の 症例 に有 意 の リンパ球幼若化 現象を認め た.幼 若化細胞 は喘 息ア レルゲ ンで最 高16.4%,若 薬物 で3.4%で あつた.比 較 的高率 を示 した症例3例 につ いて再度 観察 したが,や は り比 較的高率 の 幼化 がみ られ た.以 上 の成 績か ら,抗 原 の特異性 に問題 は残 るに して もこの ような即時 型 ア レルギー において も抗 原認識 は リンパ球 が担当 してお ...
متن کاملExposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.
BACKGROUND Exposure to traffic pollution particulate matter, predominantly diesel exhaust particles (DEPs), increases the risk of asthma and asthma exacerbation; however, the underlying mechanisms remain poorly understood. OBJECTIVE We sought to examine the effect of DEP exposure on the generation and persistence of allergen-specific memory T cells in asthmatic patients and translate these fi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1937
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.3973.438