Disopyramide pharmacokinetics and bioavailability.

Disopyramide: clinical indications, pharmacokinetics and laboratory assessment.

Disopyramide is an antiarrhythmic drug similar to quinidine and used primarily to treat ventricular ectopic systoles. Unlike quinidine which shows drug-drug interaction with digoxin, disopyramide appears to be free of this problem. Side effects include anticholinergic symptoms, cardiovascular problems, and some gastrointestinal discomfort. Disopyramide is metabolized to N-desisopropyl disopyram...

Pharmacokinetics of digoxin: interpreting bioavailability.

Three subjects were first given a digoxin tablet in the fasting state and subsequently received the same formulation in the fed state, to simulate a spurious oral bioavailability difference. As expected, when measured by peak serum digoxin concentration as well as by area under the serum digoxin concentration-time curve the bioavailability of digoxin appeared to be higher in the fasting state t...

Understanding Phenylephrine Metabolism, Pharmacokinetics, Bioavailability and Activity

Pharmacokinetics, Biodistribution and Bioavailability of Liposomal Drugs

Stealth liposomal doxorubicin (Doxil ® /Caelyx ®) passively targets to tumors through the enhanced permeability and retention (EPR) effect, which is a result of enhanced vascular permeability of tumor blood vessels. The endothelial lining of the diseased site contains gaps that can range from 380-780 nm which are large enough for the extravasation of liposomes (~100 nm). Once the liposomes are ...

Single- and Multiple-Dose Pharmacokinetics and Absolute Bioavailability of Tedizolid

OBJECTIVES Tedizolid phosphate is a novel antibacterial under investigation for the treatment of gram-positive infections. This study was conducted to assess the pharmacokinetics, safety, and tolerability of intravenous tedizolid phosphate as well as the oral bioavailability of tedizolid phosphate. DESIGN Double-blind, single-ascending dose, multiple-dose pharmacokinetics study, as well as to...