Disinhibition Bursting of Dopaminergic Neurons
نویسندگان
چکیده
منابع مشابه
Disinhibition Bursting of Dopaminergic Neurons
Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in dopaminergic neurons. We first applied constant...
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During reinforcement and sequence learning, dopaminergic neurons fire bursts of action potentials. Dopaminergic neurons in vivo receive strong background excitatory and inhibitory inputs, suggesting that one mechanism by which bursts may be produced is disinhibition. Unfortunately, these inputs are lost during slice preparation and are not precisely controlled during in vivo experiments. In the...
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Midbrain dopaminergic neurons in the substantia nigra, pars compacta and ventral tegmental area are critically important in many physiological functions. These neurons exhibit firing patterns that include tonic slow pacemaking, irregular firing and bursting, and the amount of dopamine that is present in the synaptic cleft is much increased during bursting. The mechanisms responsible for the swi...
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1 Dopaminergic Neurons 2 3 Abbreviated Title: Disinhibition of Dopaminergic Neurons 4 5 6 Collin J. Lobb, Charles J. Wilson and Carlos A. Paladini 7 Neurosciences Institute 8 University of Texas at San Antonio 9 San Antonio, TX 78249 UTSA 10 11 Corresponding Author: 12 Carlos A. Paladini ([email protected]) 13 Department of Biology 14 University of Texas at San Antonio 15 One UTSA Circle...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2011
ISSN: 1662-5137
DOI: 10.3389/fnsys.2011.00025