Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA
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منابع مشابه
Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA
BACKGROUND homB encodes a Helicobacter pylori outer membrane protein. This gene was previously associated with peptic ulcer disease (PUD) and was shown to induce activation of interleukin-8 secretion in vitro, as well as contributing to bacterial adherence. Its 90%-similar gene, homA, was previously correlated with gastritis. The present study aimed to evaluate the gastric disease association w...
متن کاملAllelic diversity among Helicobacter pylori outer membrane protein genes homB and homA generated by recombination.
Recombination is one of the main mechanisms contributing to Helicobacter pylori genomic variability. homB and homA are paralogous genes coding for H. pylori outer membrane proteins (OMPs). Both genes display allelic variation yielded by polymorphisms of the genes' middle regions, with six different alleles. This study used bioinformatic and statistical analyses to evaluate whether the allelic d...
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Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known in H. pylori, and their associated host ...
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ژورنال
عنوان ژورنال: Gut Pathogens
سال: 2009
ISSN: 1757-4749
DOI: 10.1186/1757-4749-1-12