Discrimination of prejunctional purinoceptors on adrenergic nerves in rabbit ear artery
نویسندگان
چکیده
منابع مشابه
Chronic hypoxia alters prejunctional a2-receptor function in vascular adrenergic nerves of adult and fetal sheep
Buchholz, John, and Sue P. Duckles. Chronic hypoxia alters prejunctional a2-receptor function in vascular adrenergic nerves of adult and fetal sheep. Am J Physiol Regulatory Integrative Comp Physiol 281: R926–R934, 2001.—The impact of development and chronic high-altitude hypoxia on the function of prejunctional a2-adrenoceptors was studied by measuring norepinephrine release in vitro from feta...
متن کاملBiphasic vasoconstriction of the rabbit ear artery.
Sympathetic nerve stimulation and intralummal norepinephrine infusion for more than 15 seconds produced a biphasic response in the isolated rabbit ear artery perfused with RREBS solution. This response consisted of an initial rapid constriction (phase A), which was followed by partial relaxation, and a final slowly developing constriction (phase B), which lasted for the duration of nerve stimul...
متن کاملIdentification of alpha-1L adrenoceptor in rabbit ear artery.
The alpha-1L adrenoceptor (AR) was identified in rabbit ear artery by both functional and ligand binding studies. In functional studies using arterial rings, the contractile response to NS-49 [(R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluorometh-anesulfonanilide hydrochloride] (alpha-1A and alpha-1L AR-selective agonist) was competitively antagonized with low affinities by prazosin, RS-17053 [N-[2...
متن کاملChronic hypoxia alters prejunctional alpha(2)-receptor function in vascular adrenergic nerves of adult and fetal sheep.
The impact of development and chronic high-altitude hypoxia on the function of prejunctional alpha(2)-adrenoceptors was studied by measuring norepinephrine release in vitro from fetal and adult sheep middle cerebral and facial arteries. Blockade of prejunctional alpha(2)-adrenoceptors with idazoxan significantly increased stimulation-evoked norepinephrine release in normoxic arteries. This effe...
متن کاملBiphasic constrictor response of the rabbit ear artery.
The perfused rabbit ear artery shows a biphasic contractile response to intraluminal norepinephrine and sympathetic nerve stimulation. The peak of the first phase occurs after approximately 10 seconds of exposure to NE, and the second, after IK to 2 minutes. The magnitudes of the two responses are similar. The time course of the second phase of contraction is similar to the rate of saturation o...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48019-0