Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
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چکیده
منابع مشابه
Regulation of mammalian acetyl-CoA carboxylase.
Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible phosphorylation and inactivation, and ther...
متن کاملRegulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase.
Acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] is activated by physiological concentrations of CoA. The CoA concentration dependency of this activation is sigmoidal; below 60 microM there is little or no activation, but the activation observed between 60 and 120 microM indicates that small changes in the concentration of CoA can cause significant changes in ...
متن کاملPlant acetyl-CoA carboxylase.
medium containing [” Plphosphate, the distribution of 32P-labelled acetyl-CoA carboxylase in the fractions can be investigated and it has been found that a greater proportion of the phosphorylated enzyme is present in the polymeric form after exposure of the intact tissue to insulin. Present studies are concerned with investigating whether this polymeric active form is phosphorylated to a great...
متن کاملHerbicides inhibiting acetyl-CoA carboxylase.
23 Holloway, P. J., Wong, W. W. C., Partridge, H. J., Seaman, D. and Perry, R. B. (1992) Pestic. Sci. 34, 109-118 24 Silcox, D. and Holloway, P. J. (1989) in Adjuvants and Agrochemicals (Chow, P. N. P., Grant, C. A,, Hinshalwood, A. M. and Simundsson, E., eds.), pp. 115-128, CRC Press Inc., Boca Raton, FL 25 Coret, J., Garnbonnet, B., Brabet, F. and Charnel, A. R. (1993) Pestic. Sci. 38, 201-20...
متن کاملResistance of various biotypes of Canary grass (phalaris. Spp) to acetyl-CoA carboxylase-inhibiting herbicides.
Little seed canary grass (Phalaris minor L.) is a major weed in wheat fields in some parts of Iran. To evaluate the efficacy of molecular and greenhouse methods in detecting the resistance of 49 biotypes of canary grass(Phalaris. Spp) to acetyl-CoA carboxylase-inhibiting herbicides, two methods including whole plant screening and PCR-based molecular methods were applied. Results showed that the...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2015
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.09.035