Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs
نویسندگان
چکیده
منابع مشابه
Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.
Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.2 μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermace...
متن کاملPharmacokinetics of orally administered DL-α-lipoic acid in dogs.
OBJECTIVE To determine the pharmacokinetics of DL-α-lipoic acid in dogs when administered at 3 dosages via 3 methods of delivery. ANIMALS 27 clinically normal Beagles. PROCEDURES In a 3 × 3 factorial Latin square design, 3 dosages (2.5, 12.5, and 25 mg/kg) of DL-α-lipoic acid were administered orally in a capsule form and provided without a meal, in a capsule form and provided with a meal, ...
متن کاملCGP 9000: a new orally active, broad-spectrum cephalosporin.
CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective ...
متن کاملHighly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.
A series of 3-acylaminocaprolactams are inhibitors of chemokine-induced chemotaxis. Branching of the side chain alpha-carbon provides highly potent inhibitors of a range of CC and CXC chemokines. The most potent compound has an ED(50) of 40 pM. Selected compounds were tested in an in vivo inflammatory assay, and the best compound reduces TNF-alpha levels with an ED(50) of 0.1 microg/kg when adm...
متن کاملDetection of Orally Administered
Chromatographic analysis of amantadine was achieved using an Agilent J&W CP-Sil 8 CB column. Published by Elsevier B. V. Spatial Reorganization of Saccharomyces cerevisiae Enolase To Alter Carbon Metabolism under Hypoxia Eukaryotic Cell, 12, 1106-1119 (2013) Natsuko Miura et al. Tags CP-Sil 8 CB, clinical research Abstract Derivatized metabolites in a study of yeast hypoxia were analyzed by GC/...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2016
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2016.02.019