Discovery of novel immunostimulants by dendritic-cell–based functional screening
نویسندگان
چکیده
منابع مشابه
Discovery of novel immunostimulants by dendritic-cell-based functional screening.
Immunostimulants represent an emerging class of drugs for the treatment of infectious disorders and cancer. CpG oligonucleotides and imiquimod, prototypic drugs in this category, are now known to activate dendritic cells (DCs). Here we report the development of a highly sensitive, unbiased functional screen to detect DC-stimulatory signals. Because interleukin-1beta (IL-1beta) mRNA expression i...
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ژورنال
عنوان ژورنال: Blood
سال: 2005
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2005-03-1161