Discovery Hub Genes of Radioresistance Nasopharyngeal Carcinoma using Weighted Gene Co Expression Network Analysis

To clarify the underlying mechanism of radioresistance nasopharyngeal carcinoma, we identified correlated gene modules and key genes through analyzing expression omnibus dataset with weighted co-expression network analysis. GSE32389 were obtained from omnibus. The analysis was introduced to establish a mine important genes. Gene ontology enrichment performed in which related carcinoma. Then, established proteinprotein interaction such module hub this protein-protein using molecular complex detection. Finally, analyzed these overall survival profiling interactive database. Thirty five analysis, had similar pattern. We found that light cyan most Genes mainly cytokine production, regulation cell activation immune effector process. Five discovered, namely cluster differentiation 2 molecule, interleukin 10 receptor subunit alpha, 38 beta C-C motif chemokine ligand 19. In research, mostly They involved multiple cellular processes including All may improve our basic understanding mechanisms