Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.

Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.2 μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermace...

Mode of action of a new isoxazoline compound

A new isoxazoline compound (5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3(3-methylthiophen-2-yl)-1,2-isoxazoline; code name, EK-5229) was reported to have safety in rice and control barnyardgrass (Echinochloa crus-galli), but its mode of action was unknown. The compound did not inhibit germination of sensitive grasses, but it inhibited further growth. The symptom was primarily stunting and discolo...

the innovation of a statistical model to estimate dependable rainfall (dr) and develop it for determination and classification of drought and wet years of iran

آب حاصل از بارش منبع تأمین نیازهای بی شمار جانداران به ویژه انسان است و هرگونه کاهش در کم و کیف آن مستقیماً حیات موجودات زنده را تحت تأثیر منفی قرار می دهد. نوسان سال به سال بارش از ویژگی های اساسی و بسیار مهم بارش های سالانه ایران محسوب می شود که آثار زیان بار آن در تمام عرصه های اقتصادی، اجتماعی و حتی سیاسی- امنیتی به نحوی منعکس می شود. چون میزان آب ناشی از بارش یکی از مولفه های اصلی برنامه ...

NEW DRUGS IN DERMATOLOGY Prof Dr Claude FAVROT A new class of insecticides: Isoxazoline Isoxazoline is a new class of potent insecticides including Fluralaner, afoxolaner and sarolaner

Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

Mosquitoes, such as Aedes aegypti and Anopheles gambiae, are important vectors of human diseases. Fluralaner, a recently introduced parasiticide, was evaluated as a mosquitocide in this study. On Ae. aegypti and An. gambiae fourth-instar larvae, fluralaner had 24-h LC50 (lethal concentration for 50% mortality) values of 1.8 ppb and 0.4 ppb, respectively. Following topical application to adult A...