Directed attenuation to enhance vaccine immunity

Many viral infections can be prevented by immunizing with live, attenuated vaccines. Early methods of attenuation were hit-and-miss, now much improved genetic engineering. However, even current operate on the principle harm, reducing virus’s ability to grow. Reduced growth has undesired side-effect host immune response below that infection wild-type. Might some instead lead an increased response? We use mathematical models dynamics virus innate and adaptive immunity explore tradeoff between pathology immunity. find modification immune-evasion pathways indeed reduce yet enhance Thus, vaccines can, in principle, directed safe create better than is elicited wild-type virus.