Direct regulation of ion channel by PIP2

Ion Channel Modulation by Photocaged Dioctanoyl PIP2

ION CHANNEL MODULATION BY PHOTOCAGED DIOCTANOYL PIP2 by Junghoon Ha, BSc. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Thesis Director: Diomedes E. Logothetis, Ph.D. Chair, Department of Physiology and Biophysics Phosphatidylinositol bisphosphate (PIP2) directly regul...

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidylinositol 4,5-bisphosphate (PIP(2)). Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav) channels were shown to be regulated bidirectionally by PIP(2). On on...

Ion channel regulation by protein S-acylation

Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that controls the diversity, life cycle, and physiological function of numerous ligand- and voltage-gated ion channels. S-acylation is enzymatically mediated by a diverse family of acyltransferases (zDHHCs) and is reversed by acylthioesterases....

Ion Channel Regulation by Protein Palmitoylation*

Protein S-palmitoylation, the reversible thioester linkage of a 16-carbon palmitate lipid to an intracellular cysteine residue, is rapidly emerging as a fundamental, dynamic, and widespread post-translational mechanism to control the properties and function of ligand- and voltage-gated ion channels. Palmitoylation controls multiple stages in the ion channel life cycle, from maturation to traffi...

Explorer Ion Channel Regulation by Protein Palmitoylation