Direct methods and protein crystallography at low resolution

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چکیده

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Direct methods and protein crystallography at low resolution.

The tools of modern direct methods are examined and their limitations for solving protein structures discussed. Direct methods need atomic resolution data (1.1-1.2 A) for structures of around 1000 atoms if no heavy atom is present. For low-resolution data, alternative approaches are necessary and these include maximum entropy, symbolic addition, Sayre's equation, group scattering factors and el...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section D Biological Crystallography

سال: 2000

ISSN: 0907-4449

DOI: 10.1107/s0907444900009355