Direct Interactions Between Tbid And Bcl-xlΔXl Are Enhanced In Lipid Membranes
نویسندگان
چکیده
منابع مشابه
Lipid-protein interactions in membranes.
The interactions of lipids with integral and peripheral proteins can be studied in reconstituted and natural membranes using spin label electron spin resonance (ESR) spectroscopy. The ESR spectra reveal a reduction in mobility of the spin-labelled lipid species, and in certain cases evidence is obtained for a partial penetration of the peripheral proteins into the membrane. The latter may be re...
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Sterols are main constituents of many membranes. Cholesterol is the most abundant sterol in membranes of higher organisms. Many studies have been undertaken to try to understand the function of cholesterol, in which the interaction between cholesterol and various phosphatidylcholines were investigated in monolayers and liposomes (Phillips, 1972). The physicochemical state of the lipids determin...
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The loosely bound proteins from human erythrocyte membranes induce an up to more than 103-fold increase in the electrical conductivity of black lipid membranes made from oxidized cholesterol. The conductivity increase continues until the membrane breaks. Its magnitude insreases with increasing protein concentration and salt concentration. The results are compared with earlier results obtained w...
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BIM and tBID are two BCL-2 homology 3 (BH3)-only proteins with a particularly strong capacity to trigger BAX-driven mitochondrial outer membrane permeabilization, a crucial event in mammalian apoptosis. However, the means whereby BIM and tBID fulfill this task is controversial. Here, we used a reconstituted liposomal system bearing physiological relevance to explore systematically how the BAX-p...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.2174