Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models, and Outcome Measures
نویسندگان
چکیده
منابع مشابه
Gene therapy for bone regeneration.
Nonunions and delayed unions are among the more challenging clinical and surgical entities an orthopaedic surgeon must manage. Effective strategies that address these complex problems are in need and gene therapy represents a potential therapeutic option. Among the many properties that bone morphogenetic proteins (BMPs) possess, their potent osteoinductive effects make them attractive growth fa...
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Gene therapy represents a promising approach for delivering regenerative molecules to specific tissues including bone. Several laboratories have shown that virus-based BMP expression vectors can stimulate osteoblast differentiation and bone formation in vivo. Both in vivo and ex vivo transduction of cells can induce bone formation at ectopic and orthotopic sites. Adenovirus and direct DNA deliv...
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ژورنال
عنوان ژورنال: Tissue Engineering Part B: Reviews
سال: 2010
ISSN: 1937-3368,1937-3376
DOI: 10.1089/ten.teb.2009.0156