Direct demonstration of inhibitory interactions between long interval intracortical inhibition and short interval intracortical inhibition

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Influence of short-interval intracortical inhibition on short-interval intracortical facilitation in human primary motor cortex.

Using the paired-pulse paradigm, transcranial magnetic stimulation (TMS) has revealed much about the human primary motor cortex (M1). A preceding subthreshold conditioning stimulus (CS) inhibits the excitability of the motor cortex, which is named short-interval intracortical inhibition (SICI). In contrast, facilitation is observed when the first pulse (S1) is followed by a second one at thresh...

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Dissecting the Mechanisms Underlying Short-Interval Intracortical Inhibition Using Exercise

Recently, 2 physiologically distinct phases of short-interval intracortical inhibition (SICI) have been identified, a larger phase at interstimulus interval (ISI) 3 ms and a smaller phase at ISI 1 ms. While the former is mediated by synaptic processes, the mechanisms underlying the first phase of SICI remain a matter of debate. Separately, it is known that fatiguing hand exercise reduces SICI, ...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2011

ISSN: 0022-3751

DOI: 10.1113/jphysiol.2011.207928