Direct adjusted survival and cumulative incidence curves for observational studies
نویسندگان
چکیده
منابع مشابه
Adjusted Survival Curves
Suppose we want to investigate to what extent some factor influences survival, as an example we might compare the experience of diabetic patients who are using metformin versus those on injected insulin as their primary treatment modality. There is some evidence that metformin has a positive influence, particularly in cancers, but the ascertainment is confounded by the fact that it is a first l...
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Kaplan-Meier survival curves and the associated nonparametric log rank test statistic are methods of choice for unadjusted survival analyses, while the semiparametric Cox proportional hazards regression model is used ubiquitously as a method for covariate adjustment. The Cox model extends naturally to include covariates, but there is no generally accepted method to graphically depict adjusted s...
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In rodent cancer bioassays, groups of animals are exposed to different doses of a chemical of interest and followed for tumor occurrence. The resulting tumor rates are commonly analyzed using a survival-adjusted Cochran-Armitage (CA) trend test. The CA trend test has reasonable power when the tumor-response curve is linear in dose, but it may be underpowered for a nonlinear response. An alterna...
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OBJECTIVE To detect changes in mortality after surgery, with allowance being made for variations in case mix. DESIGN Observational study of postoperative mortality from January 1992 to August 1995. SETTING Regional cardiothoracic unit. SUBJECTS 3983 patients aged 16 and over who had open heart operations. MAIN OUTCOME MEASURES Preoperative risk factors and postoperative mortality in hos...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2019
ISSN: 0268-3369,1476-5365
DOI: 10.1038/s41409-019-0552-y