Dipyrone (metamizole), overrated risks?

Dipyrone (metamizole) can nullify the antiplatelet effect of aspirin in patients with coronary artery disease.

Lysine clonixinate versus dipyrone (metamizole) for the acute treatment of severe migraine attacks: a single-blind, randomized study.

BACKGROUND AND OBJECTIVE Nonsteroidal anti-inflammatory drugs (NSAID) are effective to treat migraine attacks. Lysine clonixinate (LC) and dipyrone (metamizol) have been proven effective to treat acute migraine. The aim of this study was to evaluate the efficacy and tolerability of the intravenous formulations of LC and dipyrone in the treatment of severe migraine attacks. METHOD Thirty patie...

Metamizole (Dipyrone) as an Alternative Agent in Postoperative Analgesia in Patients with Contraindications for Nonsteroidal Anti-Inflammatory Drugs.

PURPOSE Nonsteroidal anti-inflammatory drugs (NSAIDs) play an important role in multimodal pain management. In patients with a contraindication for NSAIDs, pain management is challenging. A recent Dutch anesthesiology guideline propagates the use of metamizole (dipyrone) in these patients. Metamizole is a controversial drug, its use being previously discouraged because of the risk for agranuloc...

Lipaemia: an overrated interference?

Reagent method sheets for analysis of common serum analytes often highlight the possibility of interference from lipaemia but the information given is often brief and may not be instrument-specific. Thus study assesses the degree of interference from lipaemia in a range of common serum analytes on the Bayer Opera (with a serum blank) using a commercial polymer, LipoClear, as a lipid-clearing ag...

Ratings are Overrated!

Are ratings of any use in human–computer interaction and user studies at large? If ratings are of limited use, is there a better alternative for quantitative subjective assessment? Beyond the intrinsic shortcomings of human reporting, there are a number of supplementary limitations and fundamental methodological flaws associated with rating-based questionnaires – i.e., questionnaires that ask p...