Diphtheria tox gene polymorphism in %. diphtheriae strains isolated in Russia during 2002–2009
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چکیده
منابع مشابه
Short Communication: Diphtheria Toxin Repressor (dtxR) Gene-based Genetic Diversity of Corynebacterium diphtheriae isolated in Jakarta, Indonesia, 2018-2019
Background and Objective: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring until today. One of the causes is probably the diphtheria toxin repressor (dtxR) gene which influences toxin expression. Therefore, in this study the characterization of the gene was performed to determine the mutations that affect the DtxR protein. Methods: The dtxR genes of ...
متن کاملMolecular epidemiology of C. diphtheriae strains during different phases of the diphtheria epidemic in Belarus
BACKGROUND The reemergence of epidemic diphtheria in Belarus in 1990s has provided us with important information on the biology of the disease and the diversity of the causative agent Corynebacterium diphtheriae. Molecular investigations were conducted with the aim to analyze the genetic variability of C diphtheriae during the post-epidemic period. METHODS The biotype and toxigenicity status ...
متن کاملEvolution of C . diphtheriae strains during different phases of the diphtheria epidemic in
Valentina Kolodkina, Leonid Titov, Tatyana Sharapa, Francine Grimont, Patrick AD Grimont, Androulla Efstratiou 1 Belarusian Research Institute for Epidemiology and Microbiology, Minsk, Belarus; 2 Centre National de Reference pour Corynebacterium diphtheriae, Unite de Biodiversite des Bacteries Pathogenes Emergentes INSERM U 389, Institute Pasteur, Paris, France; 3 HPA/WHO Streptococcus and Diph...
متن کاملGenetic analysis of tox+ and tox- bacteriophages of Corynebacterium diphtheriae.
A series of mutants derived from the temperate corynebacteriophages beta(tox+), gamma(tox-), and L(tox+) was isolated and characterized. In three-factor crosses between mutant beta phages the relative map order of the genetic markers determining extended host ranges (h and h') and loss of ability to lysogenize (c) was found to be h--c--h'. Recombination between markers was observed in matings b...
متن کاملPangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia.
Corynebacterium diphtheriae is one of the most prominent human pathogens and the causative agent of the communicable disease diphtheria. The genomes of 12 strains isolated from patients with classical diphtheria, endocarditis, and pneumonia were completely sequenced and annotated. Including the genome of C. diphtheriae NCTC 13129, we herewith present a comprehensive comparative analysis of 13 s...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2010
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2010.02.501