Dipeptidyl peptidase-4 inhibition to prevent progression of calcific aortic stenosis
نویسندگان
چکیده
منابع مشابه
Targeted therapy to prevent progression of calcific aortic stenosis.
Calcific aortic valve disease is common, affecting 25% of adults over the age of 65 years, with progression to severe valve obstruction resulting in more than 50 000 aortic valve replacements annually in the United States. “Degenerative” calcific aortic valve disease was thought for many years to be a passive accumulation of calcium binding to the aortic surface of the valve leaflet. Now, convi...
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Calcific aortic stenosis is the most common indication for surgical valve replacement in the United States. For years this disease has been described as a passive degenerative process during which serum calcium attaches to the valve surface and binds to the leaflet to form nodules. Therefore, surgical treatment of this disease has been the approach toward relieving outflow obstruction in these ...
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he physical forces that impede myocardial shortening afterload) are highly relevant to pharmacologic, mechanial, and surgical treatments for left ventricular systolic ysfunction. The maintenance of a normal or near-normal fterload, matched appropriately to robust myocardial conractility and accompanied by adequate venous return and eart rate, together ensure the teleologic cardiac function of e...
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ژورنال
عنوان ژورنال: Heart
سال: 2020
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2020-317024