Dipeptidase activity in rat carrageenin granuloma.
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چکیده
منابع مشابه
Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats
Palmitoylethanolamide (PEA) and some of its analogues have shown great efficacy in the treatment of pain and inflammation. Adelmidrol - the International Nonproprietary Name (INN) of the di-amide derivative of azelaic acid - is one of these analogues. The anti-inflammatory and analgesic effects of PEA and adelmidrol are hypothesized to be mediated, at least in part, by mast cell down-modulation...
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1. Rats were mated and at weekly intervals during pregnancy and lactation, and after weaning, the dipeptidase activity in the supernatant fraction from small intestinal mucosa extracts was determined for two dipeptides: glycyl-L-leucine dipeptidase (EC 3.4.3.2) AND L-alanyl-L-glutamic acid dipeptidase. 2. Dipeptidase activity is found mainly in the soluble (spernantant) fraction of the mucosa h...
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Recombinant plant-type asparaginases from the cyanobacteria Synechocystis sp. PCC (Pasteur culture collection) 6803 and Anabaena sp. PCC 7120, from Escherichia coli and from the plant Arabidopsis thaliana were expressed in E. coli with either an N-terminal or a C-terminal His tag, and purified. Although each of the four enzymes is encoded by a single gene, their mature forms consist of two prot...
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One of the more prominent characteristics of intracellular peptidases is their remarkable susceptibility to the presence in the hydrolysis mixture of specific activators and inhibitors. The present investigation was undertaken to determine whether these relationships would remain unchanged if the activator or inhibitor were injected into the intact animal prior to the removal of the tissue to b...
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The purpose of study is to formulate and evaluate ufasomal gel of dexamethasone. Ufasomal suspension was made by sonication method using different concentrations of Span 80, Span 20 and cholesterol along with 25 mg of drug. Ufasomal gel was formulated by hydration method using carbopol 940. Ufasomal vesicles appeared as spherical and multilamellar under Transmission Electron Microscope. Ufasoma...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1978
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.26.2679