Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as c...

Recent Highlights of ATVB

Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics.

Twenty-two patients with advanced solid tumors were treated with a quinazoline folate antagonist, trimetrexate, to determine the toxicity spectrum, the maximal tolerated dose, and the pharmacokinetics of the drug. Negligible toxicity was seen with single doses of 10-70 mg/m2 given as a 1-h infusion. Single doses of 120 mg/m2 infused over 1 h caused moderate to grade 4 toxicity in five of nine p...

Recent Advances in Pharmacology

Analytical and Experimental Pharmacology, Challenges Ahead

Everybody would agree in saying that advances in Medicine, in the last decades, have lead to significant increase in life expectancy. However, the direct impact of global drug development might be harder to be precisely defined. Let then consider the following example. In the years between 1990 and 1994 AIDS was the first cause of death among people <45 in USA, with up to 40 deaths/year/100,000...