Dinucleotide insertion/deletion polymorphism in intron 50 of the COL2A1 gene
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چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولPolymorphism in the First Intron of Interferon-Gamma Gene (+874T→A) in Iranian Patients with Brucellosis
Background: Brucella is a gram-negative bacterium, causing acute and chronic infection in humans and animals. Cell-mediated immunity is the main protective immune response against Brucella spp. Activation of macrophages by IFN-γ and generation of reactive oxygen intermediates and nitric oxide are the main immunologic mechanisms responsible for control of Brucella infection. Objective: To invest...
متن کاملAssociation of COL2A1 Gene Polymorphism with Degenerative Lumbar Scoliosis
BACKGROUND Degenerative lumbar scoliosis (DLS) progresses with aging after 50-60 years, and the genetic association of DLS remains largely unclear. In this study, the genetic association between collagen type II alpha 1 (COL2A1) gene and DLS was investigated. METHODS COL2A1 gene polymorphism was investigated in DLS subjects compared to healthy controls to investigate the possibility of its as...
متن کاملDinucleotide repeat polymorphism in the human alpha-cardiac actin gene, intron IV (ACTC), detected using the polymerase chain reaction.
References: 1) Moos.M. and Gallwitz.D. (1983) EMBO J. 2, 757-761. 2) Weber.J.L. and May.P.E. (1989) Am. J. Hum. Genet. 44, 388-3%. 3) Lowe.T., Sharefkin.J., Yang.S.Q. and Dieffenbach.C.W. (1990) Nucl. Acids Res. 18, 1757-1761. Source/Description: The polymorphic sequence (TG)25 lies m intron IV, 61 bases 5' from the start of exon 5 of the human alpha-cardiac actin gene (1). The sequence was ide...
متن کاملDinucleotide repeat polymorphism in the human angiotensinogen gene.
PCR Conditions: PCR was performed in a total volume of 20 microliters with 200 ng of genomic DNA, 8 pmoles of each primer, 2 mM MgCl2, 200 mM dNTP, 50 mM KC1, 5 mM Tris-HCl, pH 8.3, 0.01% gelatin, 0.5 U Taq polymerase (Boehringer). Primer Ang5 was 5' end labeled with P 7-ATP with the resulting specific activity 0.1-0.05 /iCi/pmol. Amplification was for 35 cycles with denaturation at 94°C 1 min,...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1991
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/19.15.4305