Dilatation of Cerebral Ventricles of Rat Offsprings Induced by 6-Mercaptopurine Administration to Dams
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چکیده
منابع مشابه
Inhibition by 6-mercaptopurine of Polyarthritis Induced by Freund's Adjuvant.
Formation of granuloma and production of antibodies in guinea-pigs receiving egg albumen with Freund's adjuvant may be suppressed by cortisone (Fischel, Kabat, Stoerk, Skolnick, and Bezer, 1954). The arthritis induced in rats by Freund's adjuvant may also be prevented by treatment with cortisone (e.g. Houssay and Frangione, 1961; Pearson, Wood, and Waksman, 1961), pyrazolidines, salicylates, an...
متن کاملIn vivo metabolism of 9-methyl-6-mercaptopurine-S35 and 9-ethyl-6-mercaptopurine-S35 by the rat.
intraperitoneally to rats. The catabolic products of each of these compounds in the 24-hour urine after injection in these rats were determined. 6-MP-S36 was excreted primarily as thiouric acid. 9-Methyl and 9-ethyl-6-MP-S35 were primarily excreted unaltered, and no evidence of dealkylation was obtained. The import of these findings on the possible mechanism of action of 6-MP against neoplastic...
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15 صفحه اولEnhancement of Antibody Synthesis by 6-mercaptopurine
The administration of 6-MP to rabbits led to either suppression or enhancement of antibody production, depending on when the drug was given in relation to the antigenic challenge. Maximum enhancement of antibody synthesis was found when a small dose of BGG was administered 5 days after the last dose of a 1 wk course of 6-MP. There were no indications that the macrophage system or immunological ...
متن کاملSuppression of Allergic Uveitis by 6-mercaptopurine
Experimental uveitis in rabbits was induced by single intraocular antigen injection. Treatment with 6-MP for 14 days suppressed the allergic inflammation and antibody response. A good correlation was demonstrated between the degree of uveitis and the antibody titer.
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1967
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.91.143