منابع مشابه
Plasma digoxin levels in infants.
O'Malley, K., Coleman, E. N., Doig, W. B., and Stevenson, I. H. (1973). Archives of Disease in Childhood, 48, 55. Plasma digoxin levels in infants. The average dosage rate of digoxin given in a group of infants, when related to body surface area, was twice as high (and when related to body weight, five times as high) as that employed for the maintenance therapy of adult controls. The resulting ...
متن کاملPlasma digoxin concentration--its relation to digoxin dosage and clinical effects in patients with atrial fibrillation.
was found between digoxin dosage and plasma digoxin concentration. Patients who did not develop symptoms of digitalis intoxication until at high doses showed a slower increase ofplasma levels. At the first appearance of toxic symptoms 'steady state' values of about 6 ng digoxin/ml werefound. Excluding one divergent patient, a close inverse correlation wasfound between plasma digoxin concentrati...
متن کاملIndividual dosage of digoxin in patients with heart failure.
BACKGROUND After the publication of DIG trial, the therapeutic target of serum digoxin concentration (SDC) for the treatment of heart failure (HF) has been lowered (0.40-1.00 ng/ml). However, the majority of equations to calculate digoxin dosages were developed for higher SDCs. Recently, a new equation was validated in Asian population for low SDCs by Konishi et al., but results in Caucasians a...
متن کاملEfficiency of individual dosage of digoxin with calculated concentration
BACKGROUND Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evidence suggests that a lower concentration range (0.4-1.0 ng/mL) is preferable ...
متن کاملPostmortem tissue digoxin concentrations in infants and children.
The concentrations of digoxin in tissues of premature infants, full-term infants and older children obtained at autopsy were determined by a radioimmunoassay procedure. Infants were found to have much higher concentrations in the right and left ventricle (about 190 ng/g) than older children (about 70 ng/g) and adults as reported in the literature. Renal concentrations were lower in the prematur...
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ژورنال
عنوان ژورنال: BMJ
سال: 1979
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.6169.987-a