Digitalis intoxication.

Potassium Canrenoate and Digitalis Intoxication

Reference 1 is to Campbell's Letter to the Editor and reference 2 is to Pettinger et al., Am J Physiol 225: 234238, 1973. *P < 0.025 compared with value in 3-week-old spontaneously hypertensive rats. nous substrate and did not demonstrate that substrate remained in excess during that entire period, and (2) they did not use angiotensinase inhibitors during incubation. Incidentally, De Jong et al...

Digitalis Intoxication of the Sinoatrial Node

Background. Digitalis intoxication causes tachycardia, pacemaker shifts, and conduction disturbances in the sinoatrial (SA) node, but the mechanisms underlying these changes have not been clarified. We studied the role played by oscillatory potentials, electrical inhomogeneity, and calcium overload in cardiac steroid intoxication of the SA node. Methods and Results. Guinea pig SA nodes (isolate...

Acute digitalis intoxication--is pacing still appropriate?

Over a six year period, 92 patients intoxicated with either digitoxin or digoxin were admitted to our ICU. Fifty-one patients were treated with cardiac pacing and/or Fab fragments, and the mortality rate was 13% (14 were intoxications with digoxin, 36 with digitoxin, 1 was mixed). Forty-five cases were suicide attempts; six were accidental overdosages. Since cardiac pacing may trigger fatal arr...

Digitalis Intoxication following Conversion to Sinus Rhythm.

IN 1963 a study was published from our laboratory concerning cardiac performance during exercise before and after conversion from atrial fibrillation to sinus rhythm.' All subjects were receiving digitalis at the time of conversion. One of the findings of that study was a markedly low heart rate at exercise in sinus rhythm, much lower than expected for a group of subjects with a comparable degr...

Idioventricular Rhythm Due to Digitalis Intoxication.