Digested Ara h 1 Loses Sensitizing Capacity When Separated into Fractions
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چکیده
منابع مشابه
Digested Ara h 1 loses sensitizing capacity when separated into fractions.
The major peanut allergen Ara h 1 is an easily digestible protein under physiological conditions. The present study revealed that pepsin digestion products of Ara h 1 retained the sensitizing potential in a Brown Norway rat model, while this sensitizing capacity was lost by separating the digest into fractions by gel permeation chromatography. Protein chemical analysis showed that the peptide c...
متن کاملSensitizing Capacity When Separated into Fractions
The major peanut allergen Ara h 1 is an easily digestible protein under physiological conditions. The present study revealed that pepsin digestion products of Ara h 1 retained the sensitizing potential in a Brown Norway rat model, while this sensitizing capacity was lost by separating the digest into fractions by gel permeation chromatography. Protein chemical analysis showed that the peptide c...
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BACKGROUND Ara h 1, a vicilin; Ara h 2, a 2S albumin; and Ara h 3, a legumin, are major peanut allergens. Ara h 2 is an important predictor of clinical reactivity to peanut, but cosensitization to all 3 allergens is correlated with the severity of patients' symptoms. OBJECTIVE We investigated whether cosensitization to these 3 allergens is caused by IgE cross-reactivity, despite the fact that...
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ژورنال
عنوان ژورنال: Journal of Agricultural and Food Chemistry
سال: 2012
ISSN: 0021-8561,1520-5118
DOI: 10.1021/jf2052306