Diffusion of antibiotics in intervertebral disc
نویسندگان
چکیده
منابع مشابه
Computational Pharmacokinetics of Antibiotics Transport in the Human Intervertebral Disc
INTRODUCTION: Antibiotics as prophylactic agents are routinely administered into the human intervertebral discs via intravenous injection in order to prevent disc infection [1]. Successful intervention however requires that the drug reaches adequate inhibitory concentration levels throughout the disc. In this study and in continuation of our earlier works, the penetration time-history of antibi...
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The role of antibiotics in the treatment of disc-space infection is controversial. This study assessed the tissue penetration of flucloxacillin and cephradine into the normal intervertebral disc after intravenous administration of a bolus dose of antibiotic. Twenty-five discs were removed from 12 adolescent patients having anterior spinal surgery to correct scoliosis; antibiotic had been admini...
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Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...
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Objective: The intervertebral disc (IVD) is a highly organized matrix that serves as an articulating structure between the vertebral bodies allowing for complex spinal motion [1]. The IVD undergoes structural and morphological changes throughout the various stages of development and aging. These age-related changes can be an important part of degenerative disc disease (DDD), with associated los...
متن کاملdiffusion weighted imaging, diffusion tensor imaging, and t2* mapping of lumbar intervertebral disc in young healthy adults
conclusion adc, fa, and t2* values may quantitatively reflect the microstructural characteristics of np, therefore they could be used to detect the minimal changes of early ldd. results the adc, fa, and t2* values were different (p < 0.05) among different rois within the same disc or among corresponding rois in different level discs. while the average values of adc increased regularly with the ...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2018
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2018.06.008