Differentiation Requires Definition
نویسندگان
چکیده
منابع مشابه
Differentiation requires continuous regulation
IFFERENTIATION has long been conceived of as a series of binary decisions. Wsddington's epigenetic landscape (1940) provides a particularly vivid visual image of this concept: differentiation is likened to the path taken by a ball as it rolls down a sloped surface grooved by valleys. Similarly, according to Stuart Kauffman's binary model (1973), early choices limit later probabilities for chang...
متن کاملDifferentiation requires continuous active control.
The problems posed by differentiation that appear most soluble by a passive control mechanism can readily be solved by an active mechanism. Given the need for plasticity in gene expression in different cell types at different stages, an active mechanism may be advantageous, even essential. It is striking how few changes during differentiation are completely irreversible, the gene rearrangements...
متن کاملSpermatogonia differentiation requires retinoic acid receptor γ.
Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and RARγ (RARG). Here, we show that 1) RARG is expressed by A aligned (A(al)) spermatogonia, as well as during the transition from A(al) to A(1) spermatogonia, which is known to ...
متن کاملDifferentiation and definition of vascular-targeted therapies.
The therapeutic potential of targeting the tumor vascular supply is now widely recognized. Intense research and development activity has resulted in a variety of investigational agents, a number of which are currently in clinical development. As these novel agents are quite distinct from the cytotoxic drugs conventionally used in the treatment of solid tumors, it will be particularly important ...
متن کاملOptimal Differentiation of In Vitro Keratinocytes Requires Multifactorial External Control
For almost 30 years, keratinocyte differentiation has been studied in numerous cell models including keratinocyte primary culture with various supplemented culture media. In this respect, it has become quite difficult to draw comparisons between studies using such a variety of culture conditions. Serum-free condition with low calcium has been used to culture basal proliferating cells, though di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Higher Education
سال: 2015
ISSN: 2372-4501,1084-0613
DOI: 10.6017/ihe.2002.26.6956