Differentiation of HL-60 cells: Cell volume and cell cycle changes
نویسندگان
چکیده
منابع مشابه
Cell surface membrane protein changes during the differentiation of cultured human promyelocytic leukemia HL-60 cells.
The human promyelocytic leukemia cell line HL-60 was induced to differentiate in vitro by treatment with dimethyl sulfoxide or retinoic acid. Morphological maturation was accompanied by a total loss of transferrin binding and a 7-fold increase in the percentage of cells reducing nitro blue tetrazolium. Cell surface membrane proteins and glycoproteins were labeled with 125I by the lactoperoxidas...
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Polar solvents induce terminal differentiation in the human promyelocytic leukemia cell line HL-60. The present studies describe the functional changes that accompany the morphologic progression from promyelocytes to bands and poly-morphonuclear leukocytes (PMN) over 9 d of culture in 1.3 percent dimethylsulfoxide (DMSO). As the HL-60 cells mature, the rate of O(2-) production increase 18-fold,...
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ژورنال
عنوان ژورنال: Cytometry
سال: 1983
ISSN: 0196-4763,1097-0320
DOI: 10.1002/cyto.990030605