Differential stimulation of macrophage procoagulant activity by vascular grafts

Stimulation of helper/delayed-type hypersensitivity T cells by flavivirus infection: determination by macrophage procoagulant assay.

West Nile virus (WNV)-immune spleen cells produced an inducer of macrophage procoagulant activity (MPCA) on restimulation with WNV in vitro. This response was specific for WNV and depended on the presence of Thy 1+, L3T4+ and also Ia+ cells but not Lyt 2+ cells. It could be induced by culture with large amounts of non-infectious, u.v.-irradiated virus or with high doses of infectious virus. Ino...

Expression of macrophage procoagulant activity in murine systemic lupus erythematosus.

To explore the induction of monocyte/macrophage procoagulant activity in autoimmune disease, the BXSB murine model of systemic lupus erythematosus was studied. Splenic macrophage procoagulant activity rose coincident with age and the development of glomerulonephritis from 38 +/- 6 mU/10(6) macrophages at 1 mo to a maximum of 29,000 +/- 15,000 mU at 4 mo. Macrophages from 1-mo-old mice could be ...

Lymphocyte cooperation is required for amplification of macrophage procoagulant activity

Murine splenic lymphoid cells have been shown to possess basal procoagulant activity. This activity was localized to most macrophages by assay of cell populations, as well as by a direct plaque assay that permitted identification of expressed procoagulant activity of individual viable cells as well as content. Both content and viable expression of procoagulant activity was markedly increased by...

O N Is Required for Amplification of Macrophage Procoagulant Activity

The biological diversity of the immune system is reflected in the variety of immune effector systems and mediation pathways that have emerged. Among the least recognized involve the hemostatic pathways. The possibility of cellular and molecular linkages between two host defense mechanisms, the hemostatic and immune systems, has long been suggested, but has yet to be satisfactorily delineated. T...

Cyclosporin A regulates monocyte/macrophage effector functions by affecting instructor T cells: inhibition of monocyte procoagulant response to allogeneic stimulation.