Differential pH sensitivity of tissue superoxide dismutases
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چکیده
منابع مشابه
Differential temperature sensitivity of pea superoxide dismutases.
The activity of pea (Pisum sativum L.) Cu/Zn and Mn superoxide dismutase isoforms was evaluated across a range of temperatures from 10 to 45 degrees C. Maximal activity of the Cu/Zn and Mn superoxide dismutase isoforms was observed at 10 degrees C. Both cytoplasmic and chloroplast Cu/Zn superoxide dismutases exhibit a reduction in staining intensity with increasing temperatures. Mn superoxide d...
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Yuewei Sheng,† Isabel A. Abreu,*,‡,§ Diane E. Cabelli,* Michael J. Maroney,* Anne-Frances Miller,* Miguel Teixeira,*,‡ and Joan Selverstone Valentine*,†,∇ †Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States ‡Instituto de Tecnologia Química e Bioloǵica Antońio Xavier, Universidade Nova de Lisboa, Av. da Repub́lica, 2780-157...
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Oxidant-antioxidant balance is known to regulate growth factors and invasion of tumor cells. Manganese superoxide dismutase (MnSOD), copper zinc SOD (CuZnSOD), and extracellular SOD (ECSOD), the first-line antioxidant defenses, were studied in lung carcinomas by immunohistochemical analysis (n = 139, 56, and 37, respectively) and in 8 lung tumor specimens by Western blot analysis and SOD activi...
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O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylate...
متن کاملProkaryotic Cu,Zn superoxide dismutases.
The Cu,ZnSODs (Cu,Zn superoxide dismutases) comprise a class of ubiquitous metalloenzymes that catalyse the dismutation of the superoxide radical anion into oxygen and hydrogen peroxide. The dismutation reaction involves two successive encounters of the superoxide anion with a catalytic copper centre hosted by the enzyme at the dead end of a narrow protein channel. Cu,ZnSOD is found in all euka...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 2006
ISSN: 0970-1915,0974-0422
DOI: 10.1007/bf02912927